Searchable abstracts of presentations at key conferences in endocrinology

ea0028p169 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2012

Pravastatin does not prevent macrosomia in pregnancy complicated by maternal diabetes

Nadif Raja , Baker Bernadette , Lewis Renshall , Dilworth Mark , Sibley Colin , Baker Philip , Davidge Sandra , Aplin John , Westwood Melissa

Pregnancy complicated by pre-existing or gestational diabetes is associated with increased risk of maternal and fetal mortality and morbidity. The most common complication, macrosomia, occurs during the third trimester of pregnancy as a result of abnormal placental growth and increased transfer of nutrients to the fetus. We have previously demonstrated using an explant model of human placenta, that statins have the potential to limit placental growth. In this study we tested t...